STEM CELL THERAPY FOR INFERTILITY
What is infertility
Most people will have a strong desire to conceive a child at some point during their lifetime. Understanding what defines normal fertility is crucial to helping a person, or couple, know when it is time to seek help. Most couples (approximately 85%) will achieve pregnancy within one year of trying, with the greatest likelihood of conception occurring during the earlier months. Only an additional 7% of couples will conceive in the second year.
Infertility means not being able to get pregnant after one year of trying. Women who can get pregnant but are unable to stay pregnant may also be infertile.
Infertility may result from an issue with either you or your partner or a combination of factors that prevent pregnancy. Fortunately, there are many safe and effective therapies that significantly improve your chances of getting pregnant.
Symptoms of infertility
The main symptom of infertility is not getting pregnant. There may be no other obvious symptoms. Sometimes, a woman with infertility may have irregular or absent menstrual periods. In some cases, a man with infertility may have some signs of hormonal problems, such as changes in hair growth or sexual function.
Common Causes of Infertility
1) Advancing maternal age:
Historically before the latter 20th century, women were conceiving in their teens and twenties, when age-related abnormalities with the egg were not evident. However, in our modern era, women are delaying childbirth until their thirties and forties, which has to lead to the discovery of the adverse effect of advanced maternal age on egg function. In fact, female age-related infertility is the most common cause of infertility today.
For unknown reasons, as women age, egg numbers decrease at a rapid rate. And as aging occurs, egg quality, or the likelihood of an egg being genetically normal, decreases as well. Hence the ability to conceive a normal pregnancy decreases from when a woman is in her early 30s into her 40s. A woman is rarely fertile beyond the age of 45. This applies to the ability to conceive with her eggs, but not with donor eggs.
2) Ovulation disorders:
Normal and regular ovulation, or release of a mature egg, is essential for women to conceive naturally. Ovulation often can be detected by keeping a menstrual calendar or using an ovulation predictor kit. There are many disorders that may impact the ability of a woman to ovulate normally.
The most common disorders impacting ovulation include polycystic ovary syndrome (PCOS), hypogonadotropic hypogonadism (from signaling problems in the brain), and ovarian insufficiency (from problems of the ovary). If your cycles are infrequent or irregular, your doctor will examine you and perform the appropriate testing to discover which problem you may have and present the appropriate treatment options.
3) Tubal occlusion (blockage):
As discussed previously, a history of sexually transmitted infections including chlamydia, gonorrhea, or pelvic inflammatory disease can predispose a woman to have blocked fallopian tubes. Tubal occlusion is a cause of infertility because an ovulated egg is unable to be fertilized by sperm or to reach the endometrial cavity.
If both tubes are blocked, then in vitro fertilization (IVF) is required. If a tube is blocked and filled with fluid (called a hydrosalpinx), then minimally invasive surgery (laparoscopy or hysteroscopy) to either remove the tube or block/separate it from the uterus prior to any fertility treatments is recommended.
4) Uterine fibroids:
Fibroids are very common (approximately 40% of women may have them) and the mere presence alone does not necessarily cause infertility.
There are three types of fibroids:
1) subserosal or fibroids that extend more than 50% outside of the uterus;
2) intramural, where the majority of the fibroid is within the muscle of the uterus without any indentation of the uterine cavity; and
3) submucosal, or fibroids the project into the uterine cavity. Submucosal fibroids are the type of fibroid that has clearly been demonstrated to reduce pregnancy rate, roughly by 50%, and removal of which will double pregnancy rate. In some cases, simply removing the submucosal fibroid solves infertility. Often, but not always, submucosal fibroids can cause heavy periods or bleeding between periods.
There is more controversy regarding intramural fibroids, where larger ones may have an impact and may necessitate removal. Subserosal fibroids do not affect pregnancy. Your physician will examine you carefully to determine if you have fibroids and if removal is necessary.
5) Endometrial polyps:
Endometrial polyps are finger-like growths in the uterine cavity arising from the lining of the uterus, called the endometrium, These abnormalities are rarely associated with cancer (<1% in a woman before menopause), but polyps are can decrease fertility by up to 50% according to some studies.
Removal of polyps by the minimally invasive procedure hysteroscopy is associated with a doubling of pregnancy rate. In some cases, simply removing the polyp solves infertility.
6) Malefactors affecting sperm function:
Male factor infertility has been associated as a contributing factor causing infertility in 40-50% percent of cases, and as the sole cause for infertility in 15-20% percent of cases. If a semen analysis is found to be abnormal, generally it is first repeated to confirm the abnormality. Once confirmed, the male partner is referred to as a reproductive urologist, especially if the abnormality is severe.
In some cases, the reproductive urologist can improve semen function by recommending certain lifestyle changes, by hormonal treatments, or by surgery. In most cases, however, sperm function may not improve and therefore any attempts at pregnancy may require additional treatments or procedures performed by our clinic. Options include intrauterine insemination (also known as IUI) or IVF with intracytoplasmic sperm injection (also known as ICSI).
- Intrauterine insemination is a process by which sperm is washed and prepared for placement into the uterine cavity. Therefore, bypassing the cervix and bringing a higher concentration of motile sperm closer to the tubes and ovulated egg. At least one open tube is required for IUI, and the sperm abnormality cannot be severe otherwise the sperm will not be able to swim to and fertilize the egg.
- Intracytoplasmic sperm injection is a process by which semen is washed and prepared for direct injection of one sperm into each egg collected during the IVF process. In order to perform ICSI, an egg is held via a small suction pipette, while one sperm is injected into that egg using a very fine glass needle.
- This process bypasses the normal fertilization process, which may be compromised due to poor sperm function. Your doctor will analyze your semen analysis carefully and help you decide if ICSI is an appropriate treatment for you.
7) Endometriosis: Endometriosis is a condition whereby cells very similar to the ones lining the uterine cavity, or endometrium, are found outside the uterine cavity. It is found in approximately 10-50% of reproductive-aged women and can be associated with infertility as well as pain during intercourse and/or menstrual periods. Endometriosis causes infertility by producing inflammation and scarring, which can result in not only pain but also potentially detrimental effects on egg, sperm, or embryo.
Endometriosis can only be confirmed by surgery, usually laparoscopy. If endometriosis is found, it can be surgically removed by various methods. Its removal may lead to a decrease in pain as well as improvement in the ability to conceive naturally. Your doctor will determine if you are at risk of having endometriosis based on a careful history, physical exam, and ultrasound.
Sometimes a full evaluation does not reveal the cause of infertility. This occurs approximately 15% of the time. Thankfully, even when the cause of infertility is not known, various fertility treatments can overcome the unknown roadblock that was preventing pregnancy and eventually lead to the delivery of a healthy baby.
What are the risks factor that increases a woman infertility?
Many things can change a woman’s ability to have a baby. These include:
- Age (STC30 makes you look younger)
- Excess alcohol use
- Poor diet
- Athletic training
- Being overweight or underweight
- Sexually transmitted infections (STIs)
- Health problems that cause hormonal changes, such as polycystic ovarian syndrome and primary ovarian insufficiency
Stem Cell And Infertility
Stem cells play a significant role in the novel branch of modern Biology and Medicine, known as Regenerative Medicine. Due to their regenerative ability, stem cells are looked at as a promising tool for improving infertility treatments in women and men. It has been shown that fully mature egg cells, as well as sperm cells, can be grown in the lab, raising hope for new infertility treatments.
There has been also evidence that eggs could be fertilized, implanted into a surrogate female, and go on to produce live offspring. All the obtained offspring grew up normally without evidence of premature death. Artificially created sperm and eggs could spell the end of infertility in the near future. Stem cells can potentially be developed into any tissue in the human body.
Reproductive scientists think it is only a matter of time before the technique is used as an alternative IVF treatment. Nowadays, there is also the new trend of ovarian rejuvenation, using stem cell growth factors to improve the ovulation of older ovaries.
However, for all these techniques to become a clinical reality, many potential risks and ethical concerns about the use of stem cells must first be addressed. If the treatment works, it could be extended to even older post-menopausal women.
All this research may alter our understanding of male and female infertility and provide solutions to IVF treatments. Though a long way off, if ever, it would be an incredible change in how we view and treat infertility.
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